Pathways
High Osmolarity Pathway in Budding Yeast
Description:
The internal osmolarity of a growing yeast cell is maintained higher than the external osmolarity. The resulting osmotic gradient across the plasma membrane brings in water for cell expansion and creates turgor. Yeast cells are quite resistant to various types of stress including hypertonic stress. This adaptability can be traced to stress-activated signaling pathways that sense the stress condition and activate expression of proteins that resist the toxic effects of the stress and promote survival and eventual cell growth un...
References:
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Osmotic stress signaling and osmoadaptation in yeasts.
Microbiol Mol Biol Rev. 2002 Jun;66(2):300-72. -
A docking site determining specificity of Pbs2 MAPKK for Ssk2/Ssk22 MAPKKKs in the yeast HOG pathway.
EMBO J. 2003 Jul 15;22(14):3624-34. -
The role of adaptor protein Ste50-dependent regulation of the MAPKKK Ste11 in multiple signalling pathways of yeast.
Curr Genet. 2003 Jun;43(3):161-70. Epub 2003 Mar 11. -
The transcriptional response of Saccharomyces cerevisiae to osmotic shock. Hot1p and Msn2p/Msn4p are required for the induction of subsets of high osmolarity glycerol pathway-dependent genes.
J Biol Chem. 2000 Mar 24;275(12):8290-300.
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