Pathways
HMGB1 Pathway
Description:
The ability of a cell to respond specifically to various external and internal signals plays an essential role in regulating gene expression, differentiation, and cell death. Most often, the cellular responses to various stimuli involve transduction of signals received by specific receptors to defined targets that elicit specific responses in distinct cellular compartments. The high-mobility group box-1 (HMGB1) protein,also known as high-mobility group 1 (HMG-1) and amphoterin, is a highly conserved, abundant non-histone n...
References:
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Life after death: targeting high mobility group box 1 in emergent cancer therapies.
Am J Cancer Res. 2013;3(1):1-20. Epub 2013 Jan 18. -
Unconventional Pathways of Secretion Contribute to Inflammation.
Int J Mol Sci. 2017 Jan 5;18(1). pii: E102. doi: 10.3390/ijms18010102. Review. -
Emerging roles for HMGB1 protein in immunity, inflammation, and cancer.
Immunotargets Ther. 2015 May 26;4:101-9. doi: 10.2147/ITT.S58064. eCollection 2015. Review. -
HMGB1 increases permeability of the endothelial cell monolayer via RAGE and Src family tyrosine kinase pathways.
Inflammation. 2012 Feb;35(1):350-62. doi: 10.1007/s10753-011-9325-5.
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