Pathways
HOP Signaling
Description:
Cardiac myocyte proliferation and their differentiation early in development are dependent on the coordinate expression and action of SRF (Serum Response Factor), GATA4 (GATA Binding Protein-4) and the homeodomain factor NKX2.5 (NK2 Transcription Factor Related Locus-5). All three of these factors are expressed in developing cardiomyocytes and induce expression of cardiac genes. HOP (Homeodomain-Only Protein) physically interacts with SRF and inhibits activation of SRF-dependent transcription by inhibiting SRF binding to DNA....
References:
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Signaling and transcriptional networks in heart development and regeneration.
Cold Spring Harb Perspect Biol. 2013 Mar 1;5(3):a008292. doi: 10.1101/cshperspect.a008292. Review. -
Hopx and the Cardiomyocyte Parentage.
Mol Ther. 2015 Sep;23(9):1420-2. doi: 10.1038/mt.2015.140. No abstract available. -
The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs.
PLoS Genet. 2011 Feb;7(2):e1001313. doi: 10.1371/journal.pgen.1001313. Epub 2011 Feb 17. -
GDiscovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5.
J Med Chem. 2017 Sep 28;60(18):7781-7798. doi: 10.1021/acs.jmedchem.7b00816. Epub 2017 Sep 15.
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