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Pathways

HOP Signaling

Description:

Cardiac myocyte proliferation and their differentiation early in development are dependent on the coordinate expression and action of SRF (Serum Response Factor), GATA4 (GATA Binding Protein-4) and the homeodomain factor NKX2.5 (NK2 Transcription Factor Related Locus-5). All three of these factors are expressed in developing cardiomyocytes and induce expression of cardiac genes. HOP (Homeodomain-Only Protein) physically inte[...]

References:

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