Pathways
HSV1 Replication Cycle
Description:
HSV1 (Herpes Simplex Virus Type-1) is a member of the Herpes group of viruses, the Herpesviridiae, which includes the important human pathogens HSV2, CMV (Cytomegalovirus), Varicella zoster Virus, EBV (Epstein-Barr Virus), HSV6 and 7, and Kaposi's associated Herpes virus, HHV8 (Human Herpesvirus-8). Of these, HSV1 has been the most extensively studied. Human is the only natural host to HSV. The virus is spread by contact and the usual site for the implantation is skin or mucous membrane. Following an initial infection in epit...
References:
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Herpes simplex virus glycoprotein D bound to the human receptor HveA.
Mol Cell. 2001 Jul; 8(1):169-79. -
Herpes virus entry: an update.
J Virol. 2003 Oct; 77(19):10179-85. -
Mutations in the N termini of herpes simplex virus type 1 and 2 gDs alter functional interactions with the entry/fusion receptors HVEM, nectin-2, and 3-O-sulfated heparan sulfate but not with nectin-1.
J Virol. 2003 Sep;77(17):9221-31 -
Replication of herpes simplex virus DNA.
J Biol Chem. 1999 Oct 1; 274(40):28059-62.
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