Pathways
ICOS-ICOSL Pathway in T-Helper Cell
Description:
During immune response, T-cells are optimally activated in secondary lymphoid tissues in order to properly migrate into areas of inflamed tissue. Upon antigen recognition via the TCR (T-Cell Receptor)/CD3 (CD3 Antigen) complex, a second co-stimulatory signal from APCs or Antigen-Presenting Cells is necessary for activation of naive T-cells. According to the “Two-Signal Model” for T-cell activation, although the engagement of TCR/CD3 by antigen/MHC (Major Histocompatibility Complex) products is essential for the initial stage...
References:
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Impaired CD4 and CD8 effector function and decreased memory T cell populations in ICOS-deficient patients.
J Immunol. 2009 May 1; 182(9):5515-27. doi: 10.4049/jimmunol.0803256... -
Critical role of activation-inducible lymphocyte immunomediatory molecule/inducible costimulator in the effector function of human T cells:a comparative in vitro study of effects of its blockade and CD28blockade in human beings and monkeys.
Hum Immunol. 2008 Jul; 69(7):399-408. doi: 10.1016/j.humimm.2008.05.002. Epub 2008 Jun 17... -
Human tonsil B-cell lymphoma 6 (BCL6)-expressing CD4+ T-cell subset specialized for B-cell help outsidegerminal centers.
Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):E488-97. doi: 10.1073/pnas.1100898108. Epub 2011 Aug 1... -
Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase.
Proc Natl Acad Sci U S A. 2009 Dec 1; 106(48):20371-6. doi: 10.1073/pnas.0911573106. Epub 2009 Nov 13...
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