Pathways
IGF1R Signaling
Description:
Programmed cell death, a form of altruistic suicide is a genetically controlled means of cellular self-destruction that leads to dismantling and packaging of cell material for removal by phagocytosis. All cells possess the ability to undergo programmed cell death (otherwise known as apoptosis), and the process is essential for normal development to shape organs and tissues as well as to remove damaged cells. Although the cell may require de novo synthesis of some signaling molecules, the machinery for apoptosis is constantly ...
References:
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Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases?
Pharmacol Rev. 2010 Jun;62(2):199-236. doi: 10.1124/pr.109.002469. Epub 2010 Apr 14. Review. -
Insulin-like growth factor 1 physiology: lessons from mouse models.
Endocrinol Metab Clin North Am. 2012 Jun;41(2):231-47, v. doi: 10.1016/j.ecl.2012.04.008. Epub 2012 May 15. Review. -
Insulin-Like Growth Factor (IGF) Pathway Targeting in Cancer: Role of the IGF Axis and Opportunities for Future Combination Studies.
Target Oncol. 2017 Oct;12(5):571-597. doi: 10.1007/s11523-017-0514-5. Review. -
IGF-I elicits growth of human intestinal smooth muscle cells by activation of PI3K, PDK-1, and p70S6 kinase.
Am J Physiol Gastrointest Liver Physiol. 2003 Mar; 284(3): G411-22. Epub 2002 Nov 20.
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