Pathways
IL-27 Signaling
Description:
Interleukin-27 (IL-27) is a cytokine belonging to the IL-6/IL-12 family, characterized by its dual role in immunomodulation, encompassing both pro-inflammatory and anti-inflammatory attributes. The composition of IL-27 involves a heterodimeric configuration, consisting of the α-subunit IL-27p28, a protein structured with a four-α-helix bundle, and the β-subunit Epstein-Barr virus-induced gene 3 (EBI-3). This complex binds to the IL-27 receptor, a composite assembly comprising the gp130 subunit and the IL-27RA...
References:
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Interleukin-27: balancing protective and pathological immunity.
Immunity. 2012 Dec 14;37(6):960-9. doi: 10.1016/j.immuni.2012.11.003. -
Interleukin-27 in Tuberculosis: A Sheep in Wolf's Clothing?
Front Immunol. 2022 Jan 18;12:810602. doi: 10.3389/fimmu.2021.810602. -
IL-27-induced modulation of autoimmunity and its therapeutic potential.
Autoimmun Rev. 2015 Dec;14(12):1131-1141. doi: 10.1016/j.autrev.2015.08.001. Epub 2015 Aug 5. -
Structural insights into the assembly and activation of the IL-27 signaling complex.
EMBO Rep. 2022 Oct 6;23(10):e55450. doi: 10.15252/embr.202255450. Epub 2022 Aug 3.
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