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IL-27 Signaling


Interleukin-27 (IL-27) is a cytokine belonging to the IL-6/IL-12 family, characterized by its dual role in immunomodulation, encompassing both pro-inflammatory and anti-inflammatory attributes. The composition of IL-27 involves a heterodimeric configuration, consisting of the α-subunit IL-27p28, a protein structured with a four-α-helix bundle, and the β-subunit Epstein-Barr virus-induced gene 3 (EBI-3). This complex binds to the IL-27 receptor, a composite assembly comprising the gp130 subunit and the IL-27RA...




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