Pathways
IL-2 Gene Expression in Activated and Quiescent T-Cells
Description:
IL-2 (Interleukin-2) is a biological response modifier (cytokine), which stimulates the growth, proliferation and subsequent differentiation of disease-fighting blood cells, like T-Cells, B-Cells, NK (Natural Killer) cells, monocytes, macrophages, and oligodendrocytes. It is a powerful immunoregulatory lymphokine that was originally described as "T-Cell growth factor" and is secreted primarily by Antigen-activated T-Cells. Human IL-2 is a 133-amino acid polypeptide with a molecular mass of 15-18 kDa. In an autocr...
References:
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Interleukin-2 signaling pathway analysis by quantitative phosphoproteomics.
J Proteomics. 2011 Dec 10;75(1):177-91. Epub 2011 Jun 23. -
Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals.
J Exp Med. 2007 Jan 22;204(1):65-71. Epub 2007 Jan 16. -
Viral modulation of T-cell receptor signaling.
J Virol. 2008 May;82(9):4194-204. Epub 2008 Feb 20. Review. No abstract available. -
Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells.
Nat Immunol. 2011 Jun;12(6):478-84. Review.
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