Pathways
IL-1 Pathway
Description:
IL-1 (Interleukin-1) is a proinflammatory cytokine that stimulates a broad spectrum of immune and inflammatory responses. IL-1 is produced by activated macrophages, endothelia cells, B-Cells, and fibroblast cells. It induces inflammatory responses, edema, promotes the production of Prostaglandins, IL-2, and the growth of leukocytes (Ref.1). There are two forms of IL-1 encoded by distinct genes, IL-1 Alpha and IL-1 Beta. IL-1 Beta is produced as a 269 amino acid precursor that is cleaved by ICE (IL-1Beta Converting Enzyme) to ...
References:
-
Different Regulation of Interleukin-1 Production and Activity in Monocytes and Macrophages: Innate Memory as an Endogenous Mechanism of IL-1 Inhibition.
Front Pharmacol. 2017 Jun 8;8:335. doi: 10.3389/fphar.2017.00335. eCollection 2017. -
Interleukin-1 (IL-1) pathway.
Sci Signal. 2010 Jan 19;3(105):cm1. doi: 10.1126/scisignal.3105cm1. Review. -
The structural pathway of interleukin 1 (IL-1) initiated signaling reveals mechanisms of oncogenicmutations and SNPs in inflammation and cancer.
PLoS Comput Biol. 2014 Feb 13;10(2):e1003470. doi: 10.1371/journal.pcbi.1003470. eCollection 2014 Feb. -
Understanding the mechanism of IL-1ß secretion.
Cytokine Growth Factor Rev. 2011 Aug;22(4):189-95. doi: 10.1016/j.cytogfr.2011.10.001. Epub 2011 Oct 22. Review.
You can view details of this pathway by subscribing:
9853 Pacific Heights Blvd.
Suite D., San Diego, CA 92121, USA
Tel: 858-224-2869
Fax: 858-205-1192
info@proteinlounge.com
Databases
Tools
Institutional License
Need our databases and tools to be availed by your whole university or institute? We recommend signing up for our Site License.
To set up a license, please contact: info@proteinlounge.com
Copyright © Protein Lounge Inc.
Terms & Conditions