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IL18 Pathway


Interleukin18 (IL18) is a pro-inflammatory IL-1 family cytokine that activates hematopoietic cell types involved in Th1 and Th2 responses. IL18 plays an essential role in the host defense against various infectious microorganisms. It also enhances the induction of IFN-gamma, nitric oxide (NO), and ROS in phagocytes. Expressed by both immune and non-immune cells like macrophages, keratinocytes, osteoblasts, kupffer cells, T cells, B cells, dendritic cells, astrocytes, microglia and endothelial cells as inactive precursor pro-I...




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