Pathways
IL22 Pathway
Description:
Interleukin-22 (IL-22) is a member of the IL-10 related cytokine family which includes IL-10, IL-19, IL-20, IL-22, IL-24, and IL-26. It is generally secreted by Th17 and Th22 cells. Other immune cells like mast cells, NKT cells, natural killer22 (NK22) cells, lymphoid tissue inducer (LTi) and LTi-like cells also produce IL22. It exerts its effect on non-hematopoietic stromal cells including epithelial cells, keratinocytes, and hepatocytes.IL-22 is important for the host defense against extracellular pathogens, at muco...
References:
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IL-22, not simply a Th17 cytokine.
Immunol Rev. 2013 Mar;252(1):116-32. doi: 10.1111/imr.12027. Review. -
The Potential Role of T Helper Cell 22 and IL-22 in Immunopathogenesis of Multiple Sclerosis.
Innov Clin Neurosci. 2016 Aug 1;13(7-8):30-6. eCollection 2016 Jul-Aug. Review. -
Biological and pathological activities of interleukin-22.
J Mol Med (Berl). 2016 May;94(5):523-34. doi: 10.1007/s00109-016-1391-6. Epub 2016 Feb 29. Review. -
Interleukin-22 Signaling in the Regulation of Intestinal Health and Disease.
Front Cell Dev Biol. 2016 Jan 13;3:85. doi: 10.3389/fcell.2015.00085. eCollection 2015. Review.
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