Pathways
IL3 Pathway
Description:
Interleukin 3 (IL3) is a T cell-derived glycoprotein involved in cell proliferation, survival and differentiation. It regulates haemopoiesis, the formation of blood cells in the body. IL3, also called multi-CSF (multi-lineage colony stimulating factor), is produced by T cells and mast cells, after activation with mitogens or antigens. It was first isolated from murine bone marrow cells and is also believed to be expressed in neurons and astrocytes of the hippocampus, suggesting an important role in central nervous system...
References:
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IL-3 controls tau modifications and protects cortical neurons from neurodegeneration.
Curr Alzheimer Res. 2010 Nov;7(7):615-24. -
Interleukins and their signaling pathways in the Reactome biological pathway database.
J Allergy Clin Immunol. 2018 Apr;141(4):1411-1416. doi: 10.1016/j.jaci.2017.12.992. Epub 2018 Feb 21. -
Interleukin-3 prevents neuronal death induced by amyloid peptide.
BMC Neurosci. 2007 Oct 3;8:82. -
JAKs, STATs and Src kinases in hematopoiesis.
Oncogene. 2002 May 13;21(21):3334-58. Review.
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