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IL4 Pathway


IL4 is a multifunctional cytokine produced by TH2 type helper T cells, fibroblasts, mast cells, basophils, eosinophils, adipose, and a wide range of epithelial cells. IL4 acts on a broad range of cells, including keratinocytes, in which it induces IL6 production.   IL4 cognate receptors are of two types: I IL4R (IL4RI) and type II IL4R (IL4RII). IL4RI are mostly present on immune cells and forms heterodimer with the common gamma-chain subunits. IL4RII on the other hand is found on the surface of non-hematopoietic ...




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