Pathways
IL4 Pathway
Description:
IL4 is a multifunctional cytokine produced by TH2 type helper T cells, fibroblasts, mast cells, basophils, eosinophils, adipose, and a wide range of epithelial cells. IL4 acts on a broad range of cells, including keratinocytes, in which it induces IL6 production. IL4 cognate receptors are of two types: I IL4R (IL4RI) and type II IL4R (IL4RII). IL4RI are mostly present on immune cells and forms heterodimer with the common gamma-chain subunits. IL4RII on the other hand is found on the surface of non-hematopoietic ...
References:
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IL4 Primes the Dynamics of Breast Cancer Progression via DUSP4 Inhibition.
Cancer Res. 2017 Jun 15;77(12):3268-3279. doi: 10.1158/0008-5472.CAN-16-3126. Epub 2017 Apr 11. -
Commentary: IL-4 and IL-13 receptors and signaling.
Cytokine. 2015 Sep;75(1):38-50. doi: 10.1016/j.cyto.2015.05.023. Epub 2015 Jul 14. -
IL-4R drives dedifferentiation, mitogenesis, and metastasis in rhabdomyosarcoma.
Clin Cancer Res. 2011 May 1;17(9):2757-66. doi: 10.1158/1078-0432.CCR-10-3445. -
Interleukin-4 induces activation of mitogen-activated protein kinase and phosphorylation of shc in human keratinocytes.
J Biol Chem. 1996 Apr 12;271(15):8529-32.
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