Pathways
IL6 Pathway
Description:
IL6 (Interleukin-6) is a pleiotropic cytokine that not only affects the immune system, but also acts in other biological systems and many physiological events in various organs including the inflammation, hematopoiesis, and oncogenesis by regulating cell growth, gene activation, proliferation, survival, and differentiation. This protein signals through a receptor composed of two different subunits, an alpha subunit that produces ligand specificity and GP (Glycoprotein) 130, a receptor subunit shared in common with other cytok...
References:
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IL-6 in inflammation, immunity, and disease.
Cold Spring Harb Perspect Biol. 2014 Sep 4; 6(10):a016295. doi: 10.1101/cshperspect.a016295. Review. -
IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6.
Int J Biol Sci. 2012; 8(9):1237-47. doi: 10.7150/ijbs.4989. Epub 2012 Oct 24. Review. -
Modulation of dendritic cell differentiation by HLA-G and ILT4 requires the IL-6--STAT3 signaling pathway.
Proc Natl Acad Sci U S A. 2008 Jun 17; 105(24):8357-62. doi: 10.1073/pnas.0803341105. Epub 2008 Jun 11. -
Molecular regulation of cardiac hypertrophy.
Int J Biochem Cell Biol. 2008; 40(10):2023-39. doi: 10.1016/j.biocel.2008.02.020. Epub 2008 Feb 26. Review.
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