Pathways
ILK Signaling
Description:
ILK(Integrin-linked kinase) is a key scaffold protein that localizes to focal adhesions, acts as a central component of a heterotrimer (the ILK–PINCH–parvin complex). Since its discovery, ILK has been demonstrated to have an essential role in connecting the cytoplasmic tail of β subunits of integrins to the actin cytoskeleton, and in regulating actin polymerization. Within this pivotal position, ILK has been shown to interact with many intracellular proteins through PINCH or parvin to mediate diverse array...
References:
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Mechanisms and consequences of constitutive activation of integrin-linked kinase in acute myeloid leukemia.
Cytokine Growth Factor Rev. 2018 Oct;43:1-7. doi: 10.1016/j.cytogfr.2018.06.001. Epub 2018 Jun 7. Review. -
The role of integrin-linked kinase in the molecular architecture of focal adhesions.
J Cell Sci. 2013 Sep 15;126(Pt 18):4099-107. doi: 10.1242/jcs.120295. Epub 2013 Jul 10. -
ILK, PINCH and parvin: the tIPP of integrin signalling.
Nat Rev Mol Cell Biol. 2006 Jan;7(1):20-31. Review. -
Integrin-linked kinase: a cancer therapeutic target unique among its ILK.
Nat Rev Cancer. 2005 Jan;5(1):51-63. Review.
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