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Pathways

ILK Signaling

Description:

ILK(Integrin-linked kinase) is a key scaffold protein that localizes to focal adhesions, acts as a central component of a heterotrimer (the ILK–PINCH–parvin complex). Since its discovery, ILK has been demonstrated to have an essential role in connecting the cytoplasmic tail of β subunits of integrins to the actin cytoskeleton, and in regulating actin polymerization. Within this pivotal position, ILK has been[...]

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