Pathways
Immune Checkpoint in Cancer
Description:
Immune checkpoints are co-stimulatory or inhibitory molecules that serve as regulators of T cells function in the tumor microenvironment. Inhibitory immune checkpoints maintain immune homeostasis, down-regulate anti-tumor responses and prevent autoimmunity (Ref.1). Checkpoint pathways involve costimulatory and inhibitory receptors and their ligands. Costimulatory receptors include CD28 and ICOS (inducible T cell co-stimulator), 4-1BB, OX40, CD27, CD30, CD40, GITR (glucocorticoid inducible TNF receptor-related...
References:
-
Cancer immunotherapy by targeting immune checkpoints: mechanism of T cell dysfunction in cancer immunity and new therapeutic targets.
J Biomed Sci. 2017 May 25;24(1):35. doi: 10.1186/s12929-017-0341-0. Review. -
B7 family checkpoint regulators in immune regulation and disease.
Trends Immunol. 2013 Nov;34(11):556-63. doi: 10.1016/j.it.2013.07.003. Review. -
A Systematic Review of Immunotherapy in Urologic Cancer: Evolving Roles for Targeting of CTLA-4, PD-1/PD-L1, and HLA-G.
Eur Urol. 2015 Aug;68(2):267-79. doi: 10.1016/j.eururo.2015.02.032. Epub 2015 Mar 29. Review. -
Costimulatory and coinhibitory immune checkpoint receptors in head and neck cancer: unleashing immune responses through therapeutic combinations.
Cancers Head Neck. 2016 Oct 1;1:12. doi: 10.1186/s41199-016-0013-x. eCollection 2016. Review.
You can view details of this pathway by subscribing:
9853 Pacific Heights Blvd.
Suite D., San Diego, CA 92121, USA
Tel: 858-224-2869
Fax: 858-205-1192
info@proteinlounge.com
Databases
Tools
Institutional License
Need our databases and tools to be availed by your whole university or institute? We recommend signing up for our Site License.
To set up a license, please contact: info@proteinlounge.com
Copyright © Protein Lounge Inc.
Terms & Conditions