Pathways
Immunological Synapse
Description:
T-cell activation and effector function is mediated by the formation of a long-lasting interaction established between T-cells and APCs (Antigen-Presenting Cells) called Immunological synapse (IS). During T-cell activation, different signaling molecules as well as the cytoskeleton and the endosomal compartment are polarized to the IS. Compartmentalization of interactions at the interface of T and B cells as the central accumulation of T-cell receptor–major histocompatibility complex–peptide (TCR-MHCp) interacti...
References:
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The immunological synapse, TCR microclusters, and T cell activation.
Curr Top Microbiol Immunol. 2010;340:81-107. doi: 10.1007/978-3-642-03858-7_5. Review. -
Immunological synapse: a multi-protein signalling cellular apparatus for controlling gene expression.
Immunology. 2010 Mar;129(3):322-8. doi: 10.1111/j.1365-2567.2009.03241.x. Review. -
Signals Controlling Lytic Granule Polarization at the Cytotoxic Immune Synapse.
Front Immunol. 2018 Feb 20;9:307. doi: 10.3389/fimmu.2018.00307. eCollection 2018. Review. -
The Role of the immunological Synapse Formed by Cytotoxic Lymphocytes in Immunodeficiency and Anti-Tumor immunity.
Crit Rev Immunol. 2015;35(4):325-47. Review.
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