Inflammatory Bowel Disease

Description:

The gastrointestinal (GI) tract plays a central role in maintaining immune homeostasis, i.e., tolerance to non-pathogenic commensal bacteria, self-antigens, and food antigens, while also protecting the host against pathogenic organisms by mounting an inflammatory response. The fine line between tolerance and inflammation of the GI immune system, when disrupted, may result in diseases such as inflammatory bowel disease (IBD). IB[...]

References:

Mucosal immune system of the gastrointestinal tract: maintaining balance between the good and the bad.
Ahluwalia B, Magnusson MK, Öhman L.
Scand J Gastroenterol. 2017 Nov;52(11):1185-1193. doi: 10.1080/00365521.2017.1349173. Epub 2017 Jul 12. Review.
Immunopathogenesis of IBD: current state of the art.
de Souza HS, Fiocchi C.
Nat Rev Gastroenterol Hepatol. 2016 Jan;13(1):13-27. doi: 10.1038/nrgastro.2015.186. Epub 2015 Dec 2. Review.
The gut microbiota shapes intestinal immune responses during health and disease.
Round JL, Mazmanian SK.
Nat Rev Immunol. 2009 May;9(5):313-23. doi: 10.1038/nri2515. Review. Erratum in: Nat Rev Immunol. 2009 Aug;9(8):600.
Intestinal epithelial cells: regulators of barrier function and immune homeostasis.
Peterson LW, Artis D.
Nat Rev Immunol. 2014 Mar;14(3):141-53. doi: 10.1038/nri3608. Review.
Inflammatory bowel disease: the classic gastrointestinal autoimmune disease.
Kaistha A, Levine J.
Curr Probl Pediatr Adolesc Health Care. 2014 Dec;44(11):328-34. doi: 10.1016/j.cppeds.2014.10.003. Review.
Macrophage and dendritic cell subsets in IBD: ALDH+ cells are reduced in colon tissue of patients with ulcerative colitis regardless of inflammation.
Magnusson MK, Brynjólfsson SF, Dige A, Uronen-Hansson H, Börjesson LG, Bengtsson JL, Gudjonsson S, Öhman L, Agnholt J, Sjövall H, Agace WW, Wick MJ.
Mucosal Immunol. 2016 Jan;9(1):171-82. doi: 10.1038/mi.2015.48. Epub 2015 Jun 17.
Immunopathogenesis of inflammatory bowel disease and mechanisms of biological therapies.
Ahluwalia B, Moraes L, Magnusson MK, Öhman L.
Scand J Gastroenterol. 2018 Apr;53(4):379-389. doi: 10.1080/00365521.2018.1447597. Epub 2018 Mar 9. Review.
Role of cytokines in the pathogenesis of inflammatory bowel disease.
Papadakis KA, Targan SR.
Annu Rev Med. 2000;51:289-98. Review.

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Pathways

Inflammatory Bowel Disease

Description:

References:

Mucosal immune system of the gastrointestinal tract: maintaining balance between the good and the bad.

Immunopathogenesis of IBD: current state of the art.

The gut microbiota shapes intestinal immune responses during health and disease.

Intestinal epithelial cells: regulators of barrier function and immune homeostasis.

Inflammatory bowel disease: the classic gastrointestinal autoimmune disease.

Macrophage and dendritic cell subsets in IBD: ALDH+ cells are reduced in colon tissue of patients with ulcerative colitis regardless of inflammation.

Immunopathogenesis of inflammatory bowel disease and mechanisms of biological therapies.

Role of cytokines in the pathogenesis of inflammatory bowel disease.

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Inflammatory Bowel Disease

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References:

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