Pathways
Inhibition of Angiogenesis by TSP1
Description:
Cancer is a multistep process that includes deregulation of cell cycle, transformation, invasion of stroma, angiogenesis and metastasis. Angiogenesis is an essential component for tumor development regulated by both proangiogenic and antiangiogenic factors (Ref.1). It is a multi-step process that includes endothelial cell proliferation, migration, basement membrane degradation, and new lumen organization. Naturally occurring inhibitors of angiogenesis i.e., antiangiogenic factors are found in mammalian tissues, where they help m...
References:
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Thrombospondin-1 as a Paradigm for the Development of Antiangiogenic Agents Endowed with Multiple Mechanisms of Action.
Pharmaceuticals (Basel). 2010 Apr 23;3(4):1241-1278. Review. -
Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1.
Nat Med. 2000 Jan;6(1):41-8. -
Regulation of Cellular Redox Signaling by Matricellular Proteins in Vascular Biology, Immunology, and Cancer.
Antioxid Redox Signal. 2017 Oct 20;27(12):874-911. doi: 10.1089/ars.2017.7140. Epub 2017 Sep 8. -
Molecular basis for the regulation of angiogenesis by thrombospondin-1 and -2.
Cold Spring Harb Perspect Med. 2012 May;2(5):a006627. doi: 10.1101/cshperspect.a006627. Review.
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