Pathways
Inhibition of Matrix Metalloproteinases
Description:
MPs (Metalloproteinases) play a key role in the responses of cells to their microenvironment. By effecting proteolytic degradation or activation of cell surface and ECM (Extracellular Matrix) proteins they can modulate both cell-cell and cell-ECM interactions, which influence cell differentiation, migration, proliferation and survival. Both secreted and membrane bound forms of metalloproteinases have been implicated in pericellular proteolysis, including the MMPs (Matrix Metalloproteinases), the adamalysin-like proteinases wi...
References:
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Metalloproteinases: a Functional Pathway for Myeloid Cells.
Microbiol Spectr. 2016 Apr;4(2). doi: 10.1128/microbiolspec.MCHD-0002-2015. Review. -
Specificity of binding with matrix metalloproteinases.
EXS. 2012;103:35-56. doi: 10.1007/978-3-0348-0364-9_2. Review. -
Metalloproteinases and their inhibitors: regulators of wound healing.
Int J Biochem Cell Biol. 2008;40(6-7):1334-47. Epub 2007 Oct 26. Review. -
The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity.
Biochim Biophys Acta. 2010 Jan;1803(1):55-71. doi: 10.1016/j.bbamcr.2010.01.003. Epub 2010 Jan 15. Review.
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