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Inhibition of Ribosome Biogenesis by P14ARF


p14(ARF) is a key component of a major human tumor suppressor pathway that is responsible for arresting cell-cycle progression and inducing cell death in response to DNA damage and oncogenic stress. It plays an important role as an inhibitor of the MDM2-mediated degradation of p53. p14(ARF) activity is linked to its oligomerization and is sensitive to the redox status of the cell. Oxidative stress affects p14(ARF) oligomeriz[...]




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