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Pathways

Inhibition of Ribosome Biogenesis by P14ARF

Description:

p14(ARF) is a key component of a major human tumor suppressor pathway that is responsible for arresting cell-cycle progression and inducing cell death in response to DNA damage and oncogenic stress. It plays an important role as an inhibitor of the MDM2-mediated degradation of p53. p14(ARF) activity is linked to its oligomerization and is sensitive to the redox status of the cell. Oxidative stress affects p14(ARF) oligomerization. Tumor promotion is associated with an altered redox status, and it is known that cancer cells pr...

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