Pathways
iNOS Signaling
Description:
Microorganisms have developed several mechanisms to survive in their hosts' environments. These include competition with their hosts for metal acquisition and resistance to host defenses such as NO (Nitric Oxide), a cytotoxic weapon generated by macrophages. In eukaryotic cells, NO is metabolically produced by NOS (NO Synthase) from L-Arginine, O2 (Molecular Oxygen), and NADPH (Nicotinamide Adenine Dinucleotide, Reduced). In macrophages, an inducible NO synthase (iNOS or NOS2) is produced after activation by endotoxins or...
References:
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Nitric oxide synthases: regulation and function.
Eur Heart J. 2012 Apr;33(7):829-37, 837a-837d. doi: 10.1093/eurheartj/ehr304. Epub 2011 Sep 1. Review. -
The Characteristics and Regulatory Mechanisms of Superoxide Generation from eNOS Reductase Domain.
PLoS One. 2015 Oct 14;10(10):e0140365. doi: 10.1371/journal.pone.0140365. eCollection 2015. -
Investigating the Role of TNF-α and IFN-γ Activation on the Dynamics of iNOS Gene Expression in LPS StimulatedMacrophages.
PLoS One. 2016 Jun 8;11(6):e0153289. doi: 10.1371/journal.pone.0153289. eCollection 2016. -
Interactions between nitric oxide and hypoxia-inducible factor signaling pathways in inflammatory disease.
Nitric Oxide. 2011 Aug 1;25(2):125-37. doi: 10.1016/j.niox.2010.12.010. Epub 2011 Jan 1. Review.
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