Insulin Receptor Pathway

Description:

Insulin is the major hormone controlling critical energy functions such as glucose and lipid metabolism. Insulin elicits a diverse array of biological responses by binding to its specific receptor. The insulin receptor belongs to a subfamily of receptor tyrosine kinases that includes the IGF (Insulin-like Growth Factor) receptor and the IRR (Insulin Receptor-Related Receptor). These receptors are tetrameric proteins consisting of two alpha and two beta subunits that function as allosteric enzymes in which the alpha subunit in...

References:

Insulin receptor signaling in normal and insulin-resistant states.
Boucher J, Kleinridders A, Kahn CR.
Cold Spring Harb Perspect Biol. 2014 Jan 1;6(1). pii: a009191. doi: 10.1101/cshperspect.a009191. Review.
Minireview: nuclear insulin and insulin-like growth factor-1 receptors: a novel paradigm in signal transduction.
Sarfstein R, Werner H.
Endocrinology. 2013 May;154(5):1672-9. doi: 10.1210/en.2012-2165. Epub 2013 Mar 18. Review.
Metformin regulates glucose transporter 4 (GLUT4) translocation through AMP-activated protein kinase (AMPK)-mediated Cbl/CAP signaling in 3T3-L1 preadipocyte cells.
Lee JO, Lee SK, Kim JH, Kim N, You GY, Moon JW, Kim SJ, Park SH, Kim HS.
J Biol Chem. 2012 Dec 28;287(53):44121-9. doi: 10.1074/jbc.M112.361386. Epub 2012 Nov 7.
Direct recruitment of insulin receptor and ERK signaling cascade to insulin-inducible gene loci.
Nelson JD, LeBoeuf RC, Bomsztyk K.
Diabetes. 2011 Jan;60(1):127-37. doi: 10.2337/db09-1806. Epub 2010 Oct 7.

You can view details of this pathway by subscribing:

Subscribe Now

Pathways

Insulin Receptor Pathway

Description:

References:

Insulin receptor signaling in normal and insulin-resistant states.

Minireview: nuclear insulin and insulin-like growth factor-1 receptors: a novel paradigm in signal transduction.

Metformin regulates glucose transporter 4 (GLUT4) translocation through AMP-activated protein kinase (AMPK)-mediated Cbl/CAP signaling in 3T3-L1 preadipocyte cells.

Direct recruitment of insulin receptor and ERK signaling cascade to insulin-inducible gene loci.

Databases

Tools

Institutional License

Pathways

Insulin Receptor Pathway

Description:

References:

Insulin receptor signaling in normal and insulin-resistant states.

Minireview: nuclear insulin and insulin-like growth factor-1 receptors: a novel paradigm in signal transduction.

Metformin regulates glucose transporter 4 (GLUT4) translocation through AMP-activated protein kinase (AMPK)-mediated Cbl/CAP signaling in 3T3-L1 preadipocyte cells.

Direct recruitment of insulin receptor and ERK signaling cascade to insulin-inducible gene loci.

Databases

Tools

Institutional License

Log In