Pathways
Internalin Pathway
Description:
Listeria monocytogenes is a potentially deadly food-borne pathogen that colonizes the gastrointestinal tract of several mammalian species, and can also cause invasive disease and systemic spread if it crosses the intestinal epithelial barrier. Listeria monocytogenes evolved two major molecular invasion proteins, referred to here as invasins: Internalin A (InlA, Internalin) and Internalin B (InlB). These proteins promote internalization into nonphagocytic cells where Listeria monocytogenes can grow in the cytosol...
References:
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Listeria monocytogenes internalin B activates junctional endocytosis to accelerate intestinal invasion.
PLoS Pathog. 2010 May 13;6(5):e1000900. doi: 10.1371/journal.ppat.1000900. -
Listeria monocytogenes internalin and E-cadherin: from bench to bedside.
Cold Spring Harb Perspect Biol. 2009 Oct;1(4):a003087. doi: 10.1101/cshperspect.a003087. Review. -
A role for cofilin and LIM kinase in Listeria-induced phagocytosis.
J Cell Biol. 2001 Oct 1;155(1):101-12. Epub 2001 Sep 24. -
InlB, a surface protein of Listeria monocytogenes that behaves as an invasin and a growth factor.
J Cell Sci. 2002 Sep 1;115(Pt 17):3357-67. Review.
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