Pathways
JAK-STAT Pathway
Description:
Signaling pathways mediating the transduction of information between cells are essential for development, cellular differentiation and homeostasis. Their dysregulation is also frequently associated with human malignancies. The JAK (Janus tyrosine Kinase)-STAT (Signal Transducer and Activator of Transcription) pathway represents one such signaling cascade whose evolutionarily conserved roles include cell proliferation and haematopoiesis. JAK belongs to a family of non-receptor protein tyrosine kinases of approximately 130 kDa, co...
References:
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JAK-STAT signaling in stem cells.
Adv Exp Med Biol. 2013;786:247-67. doi: 10.1007/978-94-007-6621-1_14. -
Serum/glucocorticoid-regulated kinase 1 (SGK1) is a prominent target gene of the transcriptional response to cytokines in multiple myeloma and supports the growth of myeloma cells.
Oncogene. 2011 Jul 14;30(28):3198-206. doi: 10.1038/onc.2011.79. Epub 2011 Apr 11. -
Biology and significance of the JAK/STAT signalling pathways.
Growth Factors. 2012 Apr;30(2):88-106. doi: 10.3109/08977194.2012.660936. Epub 2012 Feb 20. Review. -
STATs: An Old Story, Yet Mesmerizing.
Cell J. 2015 Fall;17(3):395-411. Epub 2015 Oct 7. Review.
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