Pathways
JNK Pathway
Description:
MAPKs (Mitogen-Activated Protein Kinases) are Serine-threonine protein Kinases that are activated in response to a variety of extracellular stimuli and mediate signal transduction from the cell surface to the nucleus. MAPKs are expressed in multiple cell types including Cardiomyocytes, Vascular Endothelial cells, and Vascular Smooth Muscle Cells. Three major MAPKs include ERKs (Extracellular signal-Regulated Kinases), JNKs (c-Jun NH(2)-terminal protein Kinases), and p38 Kinases. Members of the JNK/SAPK (Stress-Activated Pr...
References:
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Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update.
Physiol Rev. 2012 Apr;92(2):689-737. doi: 10.1152/physrev.00028.2011. Review. -
Disassembly of the JIP1/JNK molecular scaffold by caspase-3-mediated cleavage of JIP1 during apoptosis.
Exp Cell Res. 2011 Apr 15;317(7):1028-39. doi: 10.1016/j.yexcr.2011.01.011. Epub 2011 Jan 13. -
Regulatory Roles of MAPK Phosphatases in Cancer.
Immune Netw. 2016 Apr;16(2):85-98. doi: 10.4110/in.2016.16.2.85. Epub 2016 Apr 28. Review. -
JNKs, insulin resistance and inflammation: A possible link between NAFLD and coronary artery disease.
World J Gastroenterol. 2011 Sep 7;17(33):3785-94. doi: 10.3748/wjg.v17.i33.3785. Review.
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