Pathways
LDL Oxidation in Atherogenesis
Description:
Atherosclerosis, a chronic inflammatory disease of the arterial wall, is the major cause of morbidity and mortality from CVD (Cardiovascular Disease) in much of the world’s population. The disease involves the formation of Plaques in arterial walls that narrow the arterial passage, restricting blood flow and increasing the risk of occlusion of blood flow by a myocardial infarction. There is now a consensus that Atherosclerosis represents a state of heightened oxidative stress characterized by lipid and protein oxidat...
References:
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Role of oxidative modifications in atherosclerosis.
Physiol Rev. 2004 Oct;84(4):1381-478. -
Lipoprotein aggregation protects human monocyte-derived macrophages from OxLDL-induced cytotoxicity.
J Lipid Res. 2005 Jun;46(6):1124-32. -
Is the emperor wearing clothes? Clinical trials of vitamin E and the LDL oxidation hypothesis.
Arterioscler Thromb Vasc Biol. 2001 Aug;21(8):1261-4. -
Low density lipoprotein oxidation, antioxidants, and atherosclerosis.
Curr Opin Cardiol. 2000 Sep;15(5):355-63.
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