Pathways
LDLR Biosynthesis and Transport
Description:
Cholesterol is an important component of cell membrane, and a precursor of Steroid hormones, vitamin D3, and Biliairy Acids. Cell Cholesterol homeostasis is under the control of endogenous Cholesterol synthesis, Cholesterol secretion, and of Lipoprotein Receptor activities that enrich the cell in Cholesterol. Lipoprotein Receptors play an important role in Lipoprotein metabolism and in Cellular Cholesterol homeostasis. LDLs (Low Density Lipoproteins) are the major carriers of Cholesterol as CE (Cholesteryl Esters) i...
References:
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The low-density lipoprotein receptor: ligands, debates and lore.
Curr Opin Struct Biol. 2003 Dec;13(6):683-9. Review. -
Endoplasmic reticulum localization of the low density lipoprotein receptor mediates presecretory degradation of apolipoprotein B.
Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4337-42. -
Structure of the LDL receptor extracellular domain at endosomal pH.
Science. 2002 Dec 20;298(5602):2353-8. -
Structural biology. LDL receptor's beta-propeller displaces LDL.
Science. 2002 Dec 20;298(5602):2337-9.
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