Pathways
Lectin Induced Complement Pathway
Description:
Complement is a complex system containing more than 30 various glycoproteins present in serum in the form of components, factors, or other regulators and/or on the surface of different cells in the form of receptors. It is a highly sophisticated host defence system designed to destroy pathogens. Once the complement system is activated, a chain of reactions involving proteolysis and assembly occurs, resulting in destruction of the membranes of pathogens. The cascade up to the cleavage of C3 (Complement component 3), which plays a...
References:
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Complement System Part II: Role in Immunity.
Front Immunol. 2015 May 26;6:257. doi: 10.3389/fimmu.2015.00257. eCollection 2015. Review. -
The emerging role of complement lectin pathway in trypanosomatids: molecular bases in activation, genetic deficiencies, susceptibility to infection, and complement system-based therapeutics.
ScientificWorldJournal. 2013;2013:675898. doi: 10.1155/2013/675898. Epub 2013 Feb 21. Review. -
Overview of complement activation and regulation.
Semin Nephrol. 2013 Nov;33(6):479-92. doi: 10.1016/j.semnephrol.2013.08.001. Review. -
Protection of host cells by complement regulators.
Immunol Rev. 2016 Nov;274(1):152-171. doi: 10.1111/imr.12475. Review.
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