Pathways
Macrophage Differentiation and Growth Inhibition by METS
Description:
Cell differentiation begins only when the cell proliferation mechanism is seized, and the macrophage differentiation system is a good example, as the macrophages start to differentiate only when they stop proliferating. Molecular mechanisms which act coordinately in order to regulate cell proliferation and differentiation are vital in development. Induction of Ets (v-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog) repressor that is METS (Mitogenic Ets Transcriptional Suppressor) leads to terminal differentiatio...
References:
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An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation.
Cell 2002 Apr 19;109(2):169-80. -
Differential utilization of Ras signaling pathways by macrophage colony-stimulating factor (CSF) and granulocyte-macrophage CSF receptors during macrophage differentiation.
Mol. Cell Biol. 1998 Jul; 18(7):3851-61. -
Ets domain transcription factor PE1 suppresses human interstitial collagenase promoter activity by antagonizing protein-DNA interactions at a critical AP1 element.
Biochemistry 2000 Aug 1;39(30):8917-28.
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