Pathways
MAPK Pathway in Caenorhabditis elegans
Description:
The MAPK (Mitogen-Activated Protein Kinase) pathways are highly conserved signaling cascades that convert extracellular signals into various outputs. Each pathway is composed of three classes of protein kinase: MAPK, MAPKK (MAPK Kinase) and MAPKKK (MAPK Kinase Kinase). MAPK is activated by phosphorylation of specific tyrosine and threonine residues by a family of dual-specificity protein kinase MAPKKs. MAPKK is in turn activated by phosphorylation of serine and serine/threonine residues by a family of upstream MAPKKKs. E...
References:
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Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases.
Microbiol Mol Biol Rev. 2011 Mar;75(1):50-83. doi: 10.1128/MMBR.00031-10. Review. Erratum in: Microbiol Mol Biol Rev. 2012 Jun;76(2):496. -
sli-3 negatively regulates the LET-23/epidermal growth factor receptor-mediated vulval induction pathway in Caenorhabditis elegans.
Genetics. 2006;174(3):1315-1326. doi:10.1534/genetics.106.063990 -
Context Specificity of Stress-activated Mitogen-activated Protein (MAP) Kinase Signaling: The Story as Told by Caenorhabditis elegans.
J Biol Chem. 2016 Apr 8;291(15):7796-804. doi: 10.1074/jbc.R115.711101. Epub 2016 Feb 23. Review. -
SEK-1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans.
EMBO Rep. 2002 Jan;3(1):56-62. Epub 2001 Dec 19.
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