Pathways
MAPK Pathway in Drosophila melanogaster
Description:
MAPK (Mitogen-Activated Protein Kinase) signal transduction pathways are evolutionarily conserved in eukaryotic cells and transduce signals in response to a variety of extracellular stimuli. Each pathway is composed of three classes of protein kinase: MAPK, MAPKK (MAPK Kinase) and MAPKKK (MAPK Kinase Kinase). MAPK is activated by tyrosine and threonine phosphorylation catalyzed by a family of dual-specificity protein kinase MAPKKs. MAPKK is in turn activated by phosphorylation mediated by MAPKKK. Cascades of MAPKs mediat...
References:
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Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases.
Microbiol Mol Biol Rev. 2011 Mar;75(1):50-83. doi: 10.1128/MMBR.00031-10. Review. Erratum in: Microbiol Mol Biol Rev. 2012 Jun;76(2):496. -
Genetic analysis of rolled, which encodes a Drosophila mitogen-activated protein kinase.
Genetics. 1999 Oct; 153(2): 763-71. -
Maternal control of the Drosophila dorsal-ventral body axis.
Wiley Interdiscip Rev Dev Biol. 2014 Sep-Oct;3(5):301-30. doi: 10.1002/wdev.138. Epub 2014 May 29. Review. -
Three distinct roles for notch in Drosophila R7 photoreceptor specification.
PLoS Biol. 2011 Aug;9(8):e1001132. doi: 10.1371/journal.pbio.1001132. Epub 2011 Aug 23.
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