Pathways
MAPK Pathways in Budding Yeast
Description:
MAPK (Mitogen-activated protein kinases) are serine-threonine protein kinases that are activated by diverse stimuli ranging from cytokines, growth factors, neurotransmitters, hormones, cellular stress, and cell adherence. MAPKs are expressed in all eukaryotic cells. The basic assembly of MAPK pathways is a three-component module conserved from yeast to humans. The MAPK module includes three kinases that establish a sequential activation pathway comprising a MKKK (MAPK Kinase Kinase), MKK (MAPK Kinase), and MAPK. Yeast probabl...
References:
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Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human.
Physiol Rev. 1999 Jan;79(1):143-80. -
MAP kinase dynamics in response to pheromones in budding yeast.
Nat Cell Biol. 2001 Dec;3(12):1051-9. -
Sensing, signalling and integrating physical processes during Saccharomyces cerevisiae invasive and filamentous growth.
Microbiology. 2002 Apr;148(Pt 4):893-907. -
A docking site determining specificity of Pbs2 MAPKK for Ssk2/Ssk22 MAPKKKs in the yeast HOG pathway.
EMBO J. 2003 Jul 15;22(14):3624-34.
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