Pathways
MAPK Signaling
Description:
MAPKs are a group of protein Serine/threonine Kinases that are activated in response to a variety of extracellular stimuli and mediate signal transduction from the cell surface to the nucleus. In combination with several other signaling pathways, they can differentially alter phosphorylation status of numerous proteins, including Transcription Factors, Cytoskeletal proteins, Kinases and other Enzymes, and greatly influence Gene Expression, Metabolism, Cell Division, Cell Morphology and Cell Survival. Furthermore, epigenetic a...
References:
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A network flow-based method to predict anticancer drug sensitivity.
PLoS One. 2015 May 18;10(5):e0127380. doi: 10.1371/journal.pone.0127380. eCollection 2015. -
The role of MAPK in drug-induced kidney injury.
J Signal Transduct. 2012;2012:463617. doi: 10.1155/2012/463617. Epub 2012 Mar 12. -
The ERK Cascade: Distinct Functions within Various Subcellular Organelles.
Genes Cancer. 2011 Mar;2(3):195-209. doi: 10.1177/1947601911407328. -
Non-traditional roles of G protein-coupled receptors in basic cell biology.
Mol Biosyst. 2013 Apr 5;9(4):586-95. doi: 10.1039/c2mb25429h. Review.
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