Pathways
Mating-Pheromone Response Pathway in Budding Yeast
Description:
The MAPK (Mitogen-Activated Protein Kinase) cascades play a pivotal role in many aspects of cellular functions, and are evolutionarily conserved from yeast to mammals. In Saccharomyces. cerevisiae, there are five MAP kinase signal transduction pathways that regulate mating, filamentous growth, high osmolarity response, maintenance of cellular integrity, and ascospore formation. The best-defined yeast MAPK pathway in S. cerevisae is involved in the mating of haploid cells. Yeast may exist either as haploid or diploid cells. Th...
References:
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Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human.
Physiol Rev. 1999 Jan;79(1):143-80. -
Map kinases in fungal pathogens.
Fungal Genet Biol. 2000 Dec;31(3):137-52. -
Rst1 and Rst2 are required for the a/alpha diploid cell type in yeast.
Mol Microbiol. 2002 Nov;46(3):845-54. -
Cdc42 regulation of kinase activity and signaling by the yeast p21-activated kinase Ste20.
Mol Cell Biol. 2002 May;22(9):2939-51.
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