Pathways
MDSC Induced Immune Suppression
Description:
MDSCs (Myeloid-Derived Suppressor Cells) are recently been recognized as critical mediators of tumor progression in numerous solid tumours through their inhibition of tumor-specific immune responses. These cells are increased in numerous pathologic conditions, including infections, inflammatory diseases, graft-versus-host disease, traumatic stress, and neoplastic diseases. MDSCs inhibit not only activation of T cells by anti-CD3 and super antigen, but also antigen-specific CD4+ and CD8+ T-cell responses. The mechanisms of MDS...
References:
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Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells.
Cancer Res. 2008 Jul 1;68(13):5439-49 -
Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response.
J Immunol. 2007 Jul 15;179(2):977-83. -
Pathways mediating the expansion and immunosuppressive activity of myeloid-derived suppressor cells and their relevance to cancer therapy.
Clin Cancer Res. 2007 Sep 15;13(18 Pt 1):5243-8. -
Mechanism and therapeutic reversal of immune suppression in cancer.
Cancer Res. 2007 Jun 1;67(11):5067-9.
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