Mechanism of Action of 2-Deoxy-D-Glucose on SARS-COV-2

Description:

Glucose is the most common source of cellular energy and a substrate for many biochemical processes. It is typically produced from ingested dietary carbohydrates but may also be created within the body using gluconeogenesis. Once inside the cell, glucose enters a cycle of changes to release energy in the form of ATP. Normal cells with access to oxygen utilize glycolysis to metabolize glucose into two molecules of pyruvate and form two molecules of ATP. The pyruvate is further oxidized in the mitochondria to acetyl-CoA via the...

References:

2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents.
Pajak B, Siwiak E, Sołtyka M, Priebe A, Zieliński R, Fokt I, Ziemniak M, Jaśkiewicz A, Borowski R, Domoradzki T, Priebe W.
Int J Mol Sci. 2019 Dec 29;21(1):234. doi: 10.3390/ijms21010234.
Targeting glucose metabolism for treatment of COVID-19.
Ardestani A, Azizi Z.
Signal Transduct Target Ther. 2021 Mar 6;6(1):112. doi: 10.1038/s41392-021-00532-4.
A combinatorial approach of a polypharmacological adjuvant 2-deoxy-D-glucose with low dose radiation therapy to quell the cytokine storm in COVID-19 management.
Verma A, Adhikary A, Woloschak G, Dwarakanath BS, Papineni RVL.
Int J Radiat Biol. 2020 Nov;96(11):1323-1328. doi: 10.1080/09553002.2020.1818865. Epub 2020 Oct 6.
Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2.
Gheblawi M, Wang K, Viveiros A, Nguyen Q, Zhong JC, Turner AJ, Raizada MK, Grant MB, Oudit GY.
Circ Res. 2020 May 8;126(10):1456-1474. doi: 10.1161/CIRCRESAHA.120.317015. Epub 2020 Apr 8.

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Mechanism of Action of 2-Deoxy-D-Glucose on SARS-COV-2

Description:

References:

2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents.

Targeting glucose metabolism for treatment of COVID-19.

A combinatorial approach of a polypharmacological adjuvant 2-deoxy-D-glucose with low dose radiation therapy to quell the cytokine storm in COVID-19 management.

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2.

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Mechanism of Action of 2-Deoxy-D-Glucose on SARS-COV-2

Description:

References:

2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents.

Targeting glucose metabolism for treatment of COVID-19.

A combinatorial approach of a polypharmacological adjuvant 2-deoxy-D-glucose with low dose radiation therapy to quell the cytokine storm in COVID-19 management.

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2.

Databases

Tools

Institutional License

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