Pathways
Mechanism of Nipah Infection
Description:
Nipah virus (NiV), is a highly lethal zoonotic paramyxovirus that emerged at the end of last century as a human pathogen capable of causing severe acute respiratory infection and encephalitis. NiV blocks the elicitation of innate and adaptive immune response by inhibiting synthesis of cytokines, interferon type I (IFN α/β) (Ref.1). The effects on humans of infection by Nipah virus can range from an asymptomatic infection to fatal encephalitis. The incubation period can vary from four to 45 days. The first sta...
References:
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Nano-based approach to combat emerging viral (NIPAH virus) infection.
Nanomedicine. 2019 Jun;18:196-220. doi: 10.1016/j.nano.2019.03.004. Epub 2019 Mar 21. -
Nipah virus infection: current scenario.
Indian J Virol. 2013 Dec;24(3):398-408. doi: 10.1007/s13337-013-0171-y. Epub 2013 Nov 7. -
The immune response to Nipah virus infection.
Arch Virol. 2012 Sep;157(9):1635-41. doi: 10.1007/s00705-012-1352-5. Epub 2012 Jun 6. -
Ephrin-B2 and ephrin-B3 as functional henipavirus receptors.
Semin Cell Dev Biol. 2012 Feb;23(1):116-23. doi: 10.1016/j.semcdb.2011.12.005. Epub 2011 Dec 30.
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