Mechanism of RSV Infection

Description:

Human respiratory syncytial virus (RSV) is a spherical enveloped virus with a diameter of approximately 150 nm. It is filamentous, negative-sense, single-stranded RNA virus that belongs to the Orthopneumovirus genus of the Pneumoviridae family in the order Mononegavirales. The RNA genome consists of a non-segmented negative-sense single strand RNA along with 10 genes encoding 11 proteins. They are: internal structural proteins (matrix protein [M] and nucleoprotein [N]), proteins required for a functional polymerase complex (p...

References:

Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment.
Griffiths C, Drews SJ, Marchant DJ.
Clin Microbiol Rev. 2017 Jan;30(1):277-319. Review.
A nuclear factor-κB signaling pathway via protein kinase C δ regulates replication of respiratory syncytial virus in polarized normal human nasal epithelial cells.
Masaki T, Kojima T, Okabayashi T, Ogasawara N, Ohkuni T, Obata K, Takasawa A, Murata M, Tanaka S, Hirakawa S, Fuchimoto J, Ninomiya T, Fujii N, Tsutsumi H, Himi T, Sawada N.
Mol Biol Cell. 2011 Jul 1;22(13):2144-56. doi: 10.1091/mbc.E10-11-0875. Epub 2011 May 11.
Curcumin prevents replication of respiratory syncytial virus and the epithelial responses to it in human nasal epithelial cells.
Obata K, Kojima T, Masaki T, Okabayashi T, Yokota S, Hirakawa S, Nomura K, Takasawa A, Murata M, Tanaka S, Fuchimoto J, Fujii N, Tsutsumi H, Himi T, Sawada N.
PLoS One. 2013 Sep 18;8(9):e70225. doi: 10.1371/journal.pone.0070225. eCollection 2013.
EGFR Interacts with the Fusion Protein of Respiratory Syncytial Virus Strain 2-20 and Mediates Infection and Mucin Expression.
Currier MG, Lee S, Stobart CC, Hotard AL, Villenave R, Meng J, Pretto CD, Shields MD, Nguyen MT, Todd SO, Chi MH, Hammonds J, Krumm SA, Spearman P, Plemper RK, Sakamoto K, Peebles RS Jr, Power UF, Moore ML.
PLoS Pathog. 2016 May 6;12(5):e1005622. doi: 10.1371/journal.ppat.1005622. eCollection 2016 May.

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Pathways

Mechanism of RSV Infection

Description:

References:

Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment.

A nuclear factor-κB signaling pathway via protein kinase C δ regulates replication of respiratory syncytial virus in polarized normal human nasal epithelial cells.

Curcumin prevents replication of respiratory syncytial virus and the epithelial responses to it in human nasal epithelial cells.

EGFR Interacts with the Fusion Protein of Respiratory Syncytial Virus Strain 2-20 and Mediates Infection and Mucin Expression.

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Pathways

Mechanism of RSV Infection

Description:

References:

Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment.

A nuclear factor-κB signaling pathway via protein kinase C δ regulates replication of respiratory syncytial virus in polarized normal human nasal epithelial cells.

Curcumin prevents replication of respiratory syncytial virus and the epithelial responses to it in human nasal epithelial cells.

EGFR Interacts with the Fusion Protein of Respiratory Syncytial Virus Strain 2-20 and Mediates Infection and Mucin Expression.

Databases

Tools

Institutional License

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