Pathways
Metabolic States and Circadian Oscillators
Description:
In organisms as diverse as fruit flies and mammals, circadian rhythms are controlled by a transcriptional feedback system whose activity fluctuates as a function of the light-dark cycle. In mammals, the master clock (circadian pacemaker) resides in the SCN (Suprachiasmatic Nucleus) of the brain's hypothalamus and this endogenous clock drives physiology and behavior. In the absence of external time cues, the SCN master clock generates cycles of approximately but not exactly 24 hours, and its phase must therefore be read...
References:
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Molecular components of the Mammalian circadian clock.
Handb Exp Pharmacol. 2013;(217):3-27. doi: 10.1007/978-3-642-25950-0_1. Review. -
The clock gene brain and muscle Arnt-like protein-1 (BMAL1) is involved in hair growth.
Arch Dermatol Res. 2013 Oct;305(8):755-61. doi: 10.1007/s00403-013-1403-0. Epub 2013 Aug 18. -
Regulation of circadian clock transcriptional output by CLOCK:BMAL1.
PLoS Genet. 2018 Jan 4;14(1):e1007156. doi: 10.1371/journal.pgen.1007156. eCollection 2018 Jan. -
Molecular components of the Mammalian circadian clock.
Handb Exp Pharmacol. 2013;(217):3-27. doi: 10.1007/978-3-642-25950-0_1. Review.
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