References:

• Effects of farnesyl pyrophosphate accumulation on calvarial osteoblast differentiation.

  Weivoda MM, Hohl RJ.
  Endocrinology. 2011 Aug;152(8):3113-22. doi: 10.1210/en.2011-0016. Epub 2011 May 17.

• HMG-CoA Reductase Inhibitors Bind to PPARa to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice.

  Roy A, Jana M, Kundu M, Corbett GT, Rangaswamy SB, Mishra RK, Luan CH, Gonzalez FJ, Pahan K.
  Cell Metab. 2015 Aug 4;22(2):253-65. doi: 10.1016/j.cmet.2015.05.022. Epub 2015 Jun 25.

• Simvastatin promotes adult hippocampal neurogenesis by enhancing Wnt/ß-catenin signaling.

  Robin NC, Agoston Z, Biechele TL, James RG, Berndt JD, Moon RT.
  Stem Cell Reports. 2013 Dec 26;2(1):9-17. doi: 10.1016/j.stemcr.2013.11.002. eCollection 2014 Jan 14.

• Pleiotropic vascular protective effects of statins in perioperative medicine.

  Fang SY, Roan JN, Luo CY, Tsai YC, Lam CF.
  Acta Anaesthesiol Taiwan. 2013 Sep;51(3):120-6. doi: 10.1016/j.aat.2013.08.003. Epub 2013 Sep 13. Review

• Adverse effects of statins - mechanisms and consequences.

  Beltowski J, Wójcicka G, Jamroz-Wisniewska A.
  Curr Drug Saf. 2009 Sep;4(3):209-28. Epub 2009 Sep 1. Review.

• Pleiotropic effects of statins.

  Liao JK, Laufs U.
  Annu Rev Pharmacol Toxicol. 2005;45:89-118. Review.

• Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: drug-drug interactions and interindividual differences in transporter and metabolic enzyme functions.

  Shitara Y, Sugiyama Y.
  Pharmacol Ther. 2006 Oct;112(1):71-105. Epub 2006 May 22. Review.

• Chemical, pharmacokinetic and pharmacodynamic properties of statins: an update.

  Schachter M.
  Fundam Clin Pharmacol. 2005 Feb;19(1):117-25. Review.

• Mevalonate pathway: a review of clinical and therapeutical implications.

  Buhaescu I, Izzedine H.
  Clin Biochem. 2007 Jun;40(9-10):575-84. Epub 2007 Mar 31. Review.

• Translating the effects of statins: from redox regulation to suppression of vascular wall inflammation.

  Antonopoulos AS, Margaritis M, Shirodaria C, Antoniades C.
  Thromb Haemost. 2012 Nov;108(5):840-8. doi: 10.1160/TH12-05-0337. Epub 2012 Aug 7. Review.

• Statins more than cholesterol lowering agents in Alzheimer disease: their pleiotropic functions as potential therapeutic targets.

  Barone E, Di Domenico F, Butterfield DA.
  Biochem Pharmacol. 2014 Apr 15;88(4):605-16. doi: 10.1016/j.bcp.2013.10.030. Epub 2013 Nov 11. Review.