MIF Action Through Endocytic Pathway

Description:

The cytokine MIF (Macrophage Migration Inhibitory Factor) is an integral mediator of the innate immune system. Monocytes and macrophages constitutively express large amounts of MIF, which is rapidly released after exposure to bacterial toxins and cytokines. MIF exerts potent proinflammatory activities and is an important cytokine of septic shock. MIF regulates innate immune responses to endotoxin and gram-negative bacteria b[...]

References:

Macrophage migration inhibitory factor and host innate immune defenses against bacterial sepsis.
Calandra T, Froidevaux C, Martin C, Roger T.
J Infect Dis. 2003 Jun 15; 187 Suppl 2:S385-90.
Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1.
Kleemann R, Hausser A, Geiger G, Mischke R, Burger-Kentischer A, Flieger O, Johannes FJ, Roger T, Calandra T, Kapurniotu A, Grell M, Finkelmeier D, Brunner H, Bernhagen J.
Nature. 2000 Nov 9;408(6809):211-6.
Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1.
Tomoda K, Kubota Y, Kato J.
Nature. 1999 Mar 11;398(6723):160-5.

You can get all the details on this pathway through subscription

Pathways

MIF Action Through Endocytic Pathway

Description:

References:

Macrophage migration inhibitory factor and host innate immune defenses against bacterial sepsis.

Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1.

Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1.

Databases

Tools

Institutional License

Pathways

MIF Action Through Endocytic Pathway

Description:

References:

Macrophage migration inhibitory factor and host innate immune defenses against bacterial sepsis.

Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1.

Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1.

Databases

Tools

Institutional License

Log In