Pathways
MIF Mediated Glucocorticoid Regulation
Description:
Glucocorticoids are among the most potent anti-inflammatory and immunosuppressive agents. They inhibit synthesis of almost all known cytokines, enzymes involved in the inflammatory process and of several cell surface molecules required for immune function. Glucocorticoids mediate these effects through an intracellular receptor, the GR (Glucocorticoid Receptor), a member of the steroid/thyroid hormone receptor super family. The Glucocorticoid hormones affect the metabolism of carbohydrates, proteins, and lipids in a manner n...
References:
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The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights.
Mol Cell Endocrinol. 2011 Mar 15;335(1):2-13. doi: 10.1016/j.mce.2010.04.005. Epub 2010 Apr 14. Review. -
Macrophage Migration Inhibitory Factor (MIF): A Glucocorticoid Counter-Regulator within the Immune System.
Crit Rev Immunol. 2017;37(2-6):359-370. doi: 10.1615/CritRevImmunol.v37.i2-6.90. Review. -
Mechanisms of NF-?B p65 and strategies for therapeutic manipulation.
J Inflamm Res. 2018 Oct 30;11:407-419. doi: 10.2147/JIR.S140188. eCollection 2018. Review. -
The macrophage migration inhibitory factor-glucocorticoid dyad: regulation of inflammation and immunity.
Mol Endocrinol. 2007 Jun;21(6):1267-80. Epub 2007 Mar 27. Review.
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