Pathways
MIF Regulation of Innate Immune Cells
Description:
The innate immune response to bacteria is essential for survival but the systemic release of inflammatory mediators results in the life-threatening Septic-shock reaction. Macrophages are essential effector cells of innate immunity that play a pivotal role in the recognition and elimination of invasive microorganisms. Mediators released by activated macrophages orchestrate innate and adaptive immune host responses. The cytokine MIF (Macrophage Migration Inhibitory Factor) is an integral mediator of the innate immune system. Monoc...
References:
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The role of macrophages in the innate immune response to Streptococcus pneumoniae and Staphylococcus aureus: mechanisms and contrasts.
Adv Microb Physiol. 2014;65:125-202. doi: 10.1016/bs.ampbs.2014.08.004. Epub 2014 Nov 4. Review. -
High expression levels of macrophage migration inhibitory factor sustain the innate immune responses of neonates.
Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E997-1005. doi: 10.1073/pnas.1514018113. Epub 2016 Feb 8. -
Harmful molecular mechanisms in sepsis.
Nat Rev Immunol. 2008 Oct;8(10):776-87. doi: 10.1038/nri2402. Review. -
Macrophage migration inhibitory factor, Toll-like receptor 4, and CD14 polymorphisms with altered expression levels in patients with ulcerative colitis.
Hum Immunol. 2012 Feb;73(2):201-5. doi: 10.1016/j.humimm.2011.12.006. Epub 2011 Dec 8.
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