Pathways
Mismatch Repair in Prokaryotes
Description:
The integrity of genetic information depends on the fidelity of DNA replication and on the efficiency of several different DNA repair processes. Among many types of DNA repair, the general MMR (DNA Mismatch Repair) pathway is responsible for correcting base substitution mismatches which is generated during DNA replication in organisms from bacteria to mammals. The MMR system improves the fidelity of DNA synthesis by 100-1000 fold. The MMR also corrects IDLs (Insertion-Deletion Loops) which may occur during replication and rec...
References:
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Excision repair invades the territory of mismatch repair.
Nat Genet. 1999 Mar; 21(3):247-9. -
DNA mismatch repair.
Annu Rev Biochem. 2005;74:681-710 -
Deletion mutation analysis of the mutS gene in Escherichia coli.
J Biol Chem. 1999 Feb 26;274(9):5948-52. -
Mechanisms and functions of DNA mismatch repair.
Cell Res. 2008 Jan;18(1):85-98.
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