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  1. Home  >  Pathways  >  Mitochondrial Apoptosis

Mitochondrial Apoptosis

Description:

Apoptosis is a naturally occurring process by which a cell is directed to Programmed Cell Death. Apoptosis is based on a genetic program that is an indispensable part of the development and function of an organism. In this process, cells that are no longer needed or that will be detrimental to an organism or tissue are disposed of in a neat and orderly manner; this prevents the development of an inflammatory response, which is often associated with Necrotic cell death. There are at least two broad pathways that lead to Apoptosis...

References:

  • Broad targeting of resistance to apoptosis in cancer.
    Mohammad RM, Muqbil I, Lowe L, Yedjou C, Hsu HY, Lin LT, Siegelin MD, Fimognari C, Kumar NB, Dou QP, Yang H, Samadi AK, Russo GL, Spagnuolo C, Ray SK, Chakrabarti M, Morre JD, Coley HM, Honoki K, Fujii H, Georgakilas AG, Amedei A, Niccolai E, Amin A, Ashraf SS, Helferich WG, Yang X, Boosani CS, Guha G, Bhakta D, Ciriolo MR, Aquilano K, Chen S, Mohammed SI, Keith WN, Bilsland A, Halicka D, Nowsheen S, Azmi AS.
    Semin Cancer Biol. 2015 Dec;35 Suppl:S78-S103. doi: 10.1016/j.semcancer.2015.03.001. Epub 2015 Apr 28. Review.
  • Apoptosis and molecular targeting therapy in cancer.
    Hassan M, Watari H, AbuAlmaaty A, Ohba Y, Sakuragi N.
    Biomed Res Int. 2014;2014:150845. doi: 10.1155/2014/150845. Epub 2014 Jun 12. Review.
  • Fas death receptor signalling: roles of Bid and XIAP.
    Kaufmann T, Strasser A, Jost PJ.
    Cell Death Differ. 2012 Jan;19(1):42-50. doi: 10.1038/cdd.2011.121. Epub 2011 Sep 30. Review.
  • Cellular mechanisms controlling caspase activation and function.
    Parrish AB, Freel CD, Kornbluth S.
    Cold Spring Harb Perspect Biol. 2013 Jun 1;5(6). pii: a008672. doi: 10.1101/cshperspect.a008672. Review.
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