Pathways
Mitochondrial CPT System
Description:
Mitochondrial fatty acid oxidation (FAO) and its key rate-limiting enzyme, the carnitine palmitoyltransferase (CPT) system, are important for energy homeostasis in situations like fasting or during exercise. They also regulate host immune responses and the deficiency or over-activation of CPT may cause energy metabolism disorder that may lead to many diseases starting from inflammatory disorders to cancer. Fatty acid catabolism occurs mostly in mitochondria through the beta-oxidation pathway (Ref.1 and 2). Long-chain fa...
References:
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Carnitine Palmitoyltransferase System: A New Target for Anti-Inflammatory and Anticancer Therapy?
Front Pharmacol. 2021 Oct 26;12:760581. doi: 10.3389/fphar.2021.760581. -
Carnitine palmitoyltransferases 1 and 2: biochemical, molecular and medical aspects.
Mol Aspects Med. 2004 Oct-Dec;25(5-6):495-520. doi: 10.1016/j.mam.2004.06.004. -
Muscle Carnitine Palmitoyltransferase II (CPT II) Deficiency: A Conceptual Approach.
Molecules. 2020 Apr 13;25(8):1784. doi: 10.3390/molecules25081784. -
Carnitine transport and fatty acid oxidation.
Biochim Biophys Acta. 2016 Oct;1863(10):2422-35.doi: 10.1016/j.bbamcr.2016.01.023. Epub 2016 Jan 29.
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