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Mitochondrial CPT System


Mitochondrial fatty acid oxidation (FAO) and its key rate-limiting enzyme, the carnitine palmitoyltransferase (CPT) system, are important for energy homeostasis in situations like fasting or during exercise. They also regulate host immune responses and the deficiency or over-activation of CPT may cause energy metabolism disorder that may lead to many diseases starting from inflammatory disorders to cancer.  Fatty acid catabolism occurs mostly in mitochondria through the beta-oxidation pathway (Ref.1 and 2). Long-chain fa...




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