Pathways
Mitochondrial Protein Import Pathways
Description:
Eukaryotic cells are characterized by extensive subcellular compartmentation whose structural basis is the existence of a number of highly specialized membrane-bound organelles. Each of these organelles is equipped with a specific subset of proteins allowing them to fulfill specific tasks in cellular metabolism. Mitochondria are present in virtually all eukaryotic cells. Mitochondria are the compartments responsible for respiration and oxidative phosphorlyation. They are made up of two highly specialized membrane systems, the OM...
References:
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Mitochondrial protein import: common principles and physiological networks.
Biochim Biophys Acta. 2013 Feb;1833(2):274-85. doi: 10.1016/j.bbamcr.2012.05.028. Epub 2012 Jun 7. Review. -
Mitochondrial Machineries for Protein Import and Assembly.
Annu Rev Biochem. 2017 Jun 20;86:685-714. doi: 10.1146/annurev-biochem-060815-014352. Epub 2017 Mar 15. Review. -
Hsp70 at the membrane: driving protein translocation.
BMC Biol. 2018 Jan 17;16(1):11. doi: 10.1186/s12915-017-0474-3. Review. -
Mechanisms of protein sorting in mitochondria.
Cold Spring Harb Perspect Biol. 2012 Oct 1;4(10). pii: a011320. doi: 10.1101/cshperspect.a011320. Review.
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