Pathways
Mitotic Roles of Polo Like Kinases
Description:
Cell division is characterized by orchestrated events of chromosome segregation, distribution of cellular organelles, and the eventual partitioning and separation of the two daughter cells. Mitosis is a highly regulated process that assures the proper allotment of genetic material between each pair of daughter cells. It proceeds through successive stages of well-defined and coordinated sub-processes. Entry into mitosis is regulated by the CDC2 (Cell Division Cycle-2)/Cyclin-B heterodimer. CDC2/Cyclin-B activity drives th...
References:
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Signaling pathways that regulate cell division.
Cold Spring Harb Perspect Biol. 2012 Oct 1;4(10). pii: a005942. doi: 10.1101/cshperspect.a005942. Review. -
Polo-like kinases (plks), a key regulator of cell cycle and new potential target for cancer therapy.
Proc Natl Acad Sci U S A. 1999 Dec 7; 96(25): 14360-5. -
Pathways for genome integrity in G2 phase of the cell cycle.
Biomolecules. 2012 Nov 30;2(4):579-607. doi: 10.3390/biom2040579. Erratum in: Biomolecules. 2013;3(1):72-4. -
Functional relationship among PLK2, PLK4 and ROCK2 to induce centrosome amplification.
Cell Cycle. 2015;14(4):544-53. doi: 10.4161/15384101.2014.989121.
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