Pathways
MNAR-PELP1 and Estrogen Receptor Interaction
Description:
Estrogen contributes to the development of three of the top five cancers of women--those of the breast, uterus, and ovaries--which together account for an estimated 240,000 new cancer cases a year in the United States alone (Ref.1). The ER (Estrogen Receptor) signaling pathway is implicated in the progression of cancer tumorigenesis and the activity of the hormone receptor is regulated by ligands (Estrogens), and coactivators or corepressors (Ref.2). MNAR (Modulator of Nongenomic Activity Of Estrogen Receptor)/PELP1 (Pro...
References:
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Rapid signaling mechanisms of estrogens in the developing cerebellum.
Brain Res Rev. 2008 Mar;57(2):481-92. Epub 2007 Sep 14. Review. -
Role of estrogen receptor signaling in breast cancer metastasis.
Int J Breast Cancer. 2012;2012:654698. doi: 10.1155/2012/654698. Epub 2011 Dec 19. -
Functional interactions between the estrogen receptor coactivator PELP1/MNAR and retinoblastoma protein.
J Biol Chem. 2003 Jun 13;278(24):22119-27. Epub 2003 Apr 7. -
Cloning and functional characterization of PELP1/MNAR promoter.
Gene. 2004 Apr 14;330:115-22.
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